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Understanding these contributing mechanisms enables healthcare providers to implement targeted management strategies, optimize treatment tolerability, and distinguish medication-related fatigue from potentially serious underlying conditions requiring further evaluation

This suggests that ART, in combination with residual HIV-induced inflammation, may contribute to accelerated biological aging(inflammaging), potentially underlying the increased risk of age-related comorbidities such as neurocognitive decline, cardiovascular disease, and frailty observed in PLWH (114)

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Your clinician remains available for ongoing support, dose adjustments, and side-effect management