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Common side effects include gastrointestinal issues, which typically decrease over time

Conversely, sacubitril/valsartan has been shown to increase PRA, ANG I and ANG II levels in a canine model of RAAS activation

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In general, if the patient comes in, is recognized as high risk for cardiovascular disease with the associated diseases I just discussed and with a certain BMI, I would have to say my opinion that they definitely outweigh any risks," Dr