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Clujul Med (2018) 91(1):1179

While not FDA-approved specifically for weight loss, metformin typically produces modest weight reduction of 1-3 kg (approximately 2-3% of body weight), possibly through decreased appetite, potential effects on gut microbiome composition, and metabolic effects on cellular energy pathways

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Current recommendations suggest that women stop GLP-1 medications when planning a pregnancy or as soon as they find out they are pregnant and not to resume until they have finished breastfeeding