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found that NLRP3, gasdermin D (GSDMD), cleaved caspase-1, and cleaved IL-1 levels were upregulated in acute hypobaric hypoxia rats (6000 m, exposure for 3 days), suggesting that acute hypobaric hypoxia could activate the NLRP3/caspase-1 signaling pathway in heart tissue of acute hypobaric hypoxia-induced heart injury rats (Shen et al., 2023)

Researchers believe this may be because insurance coverage is more consistent for diabetes treatment than for weight loss