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The authors of the study explain that there are around 5000 different chemicals in tobacco smoke but nicotine seems to be the main culprit here

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Washington, DC, May 29, 2023 (PAHO)- While the percentage of the population using tobacco in the Americas declined from 28% to 16.3% between 2000 and 2020, novel products and misleading information from the tobacco industry, especially targeting young people, threaten to undo those gains

About 95 percent of adult smokers begin smoking before they turn 21, according to the Campaign for Tobacco-free kids