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In addition, we provide a mechanistic understanding of how reward processing may be altered at the level of the VTA in response to chronic nicotine

The analyses in Table 6 were repeated without adjusting for BMI or for cholesterol, in case these variables were on the causal pathway between smoking or alcohol and mortality (Additional file 1: Table S1)

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Difficulty Eating and Speaking: Reduced saliva production can make chewing and swallowing uncomfortable and may affect speech