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According to the Global Burden of Disease (GBD) 2022 study, cancer causes nearly 10 million deaths annually, accounting for 16.8% of all deaths worldwide ( Tobacco use is the most important modifiable risk factor for cancer and is strongly associated with at least 20 cancer types ( The burden of cancer caused by tobacco use is highly preventable

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In Portugal in the mid-16th century, doctors began to use tobacco for purely medicinal purposes