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Compared with traditional meta-analysis using linear mixed effect models, MR-BRT relaxes the assumption of a log(linear) relationship between exposure and risk, incorporates between-study heterogeneity into the uncertainty of risk estimates, handles estimates reported across different exposure categories, automatically identifies and trims outliers, and systematically tests and adjusts for bias due to study designs and characteristics

Financial Burden of Substance Abuse Drug abuse can lead to significant financial strain, affecting both the individual and their loved ones

Types of nicotine span traditional tobacco-derived forms, synthetic nicotine, and modern oral formats such as pouches, gums, and lozenges, each serving different regulatory and consumer needs

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