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These dropouts result in delays, loss of critical data, and the financial burden of recruiting replacements

However, in recent years autophagy emerged as a selective process that degrades potentially dangerous cellular materials ranging from misfolded proteins and protein aggregates to damaged mitochondria and intracellular bacteria ( 1.1 The mechanism of autophagy Generally, autophagy consists of four distinct phases: (1) initiation, (2) nucleation, (3) elongation, (4) fusion and degradation, which involve many protein complexes required for autophagosome biogenesis, trafficking, fusion with lysosomes, and cargo degradation ( 1.1.1 Initiation During the initiation of autophagy, the Unc-51-like kinase (ULK) complex, consisting of either ULK1 or ULK2 (a serine/threonine kinase), RB1-inducible coiled-coil protein 1 (FIP200), autophagy related protein 13 (ATG13) and autophagy related protein 101 (ATG101), induces the formation of autophagosomes by acting as a scaffold to recruit autophagic machinery ( Under high nutrient availability, mTORC1 is activated and negatively regulates the ULK complex by directly binding and inactivating ULK1 and ATG13 by phosphorylation

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The brain capillary pericytes respond to neuronal and astrocytic signals by regulating intracellular Ca 2+ and K + , leading to either hyperpolarization or depolarization, thereby influencing CBF