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Studies have shown that DSIP modifies opioid tolerance and dependence in animal models and possesses its own analgesic activity independent of classical opioid receptors

Load Distribution: The meniscus distributes body weight across the knee joint, reducing stress on the bones

The lack of evidence is not surprising given the many definitions of the disorder employed and the focus of most trials on National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) diagnostic criteria (note that the NIDDK diagnostic criteria are not appropriate for use outside of clinical trials)