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These include larger registration studies such as ATTAIN-HYPERTENSION and smaller studies to evaluate blood pressure alongside weight loss, such as SOLUTION-Pilot

Results from initial clinical trials suggest that GLP-1 medications promote smoking abstinence, reduce nicotine craving and withdrawal, and prevent weight gain that frequently occurs with smoking cessation

When calories are restricted or food intake changes rapidly, hormonal systems respond by increasing hunger signals and reducing metabolic efficiency

Similarly, in IBS, treatments like ROSE-010 show varying efficacy depending on gender, which limits generalizability and underscores the need for more personalized therapeutic approaches