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Amphetamines disrupt VMAT2 function and vesicular uptake through a combination of mechanisms: The Weak Base Effect (pH Gradient Collapse) : Amphetamines are lipophilic weak bases (pKa of 9.9) that can readily diffuse across both the plasma and vesicular membranes to accumulate inside synaptic vesicles (Wimalasena 2011)

This peripheral mechanism complements central appetite suppression

This medication offers significant promise by potentially reducing body weight by up to 18% for some users

Optum Rx Weight Engage offers clinically appropriate programs that support wellness and better health for consumers and solutions to help clients manage drug spending, said Patrick Conway, M.D., CEO of Optum Rx, in the release