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Its so controversial because of the way it works: by triggering a chemical repugnance to food itself

Cancers 16(9):1625 De Ycaza AE, Brito JP, McCoy RG, Shao H, Singh Ospina N (2024) Glucagon-like peptide-1 receptor agonists and thyroid cancer: a narrative review

For example, consuming 200 mg caffeine has been shown to increase energy expenditure by up to 7% over a 3-hour period, whilst regular caffeine intake at 2-hour intervals throughout the day can increase total daily energy expenditure by up to 150 kcal

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