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It shows that when compared with the wild type, the deletion of gr resulted in the upregulation of peroxiredoxin and heterodisulfide reductase subunit C and the downregulation of thioredoxin reductase, glutathione S-transferase, and sulfur dioxygenase after incubation for 1 h

In fact, there is a significant inverse linear correlation between riboflavin intake and MDA, a lipid peroxide, as found in a Moscow-based cross-sectional study ( Figure 1 First, glutathione is a major endogenous antioxidant against oxidative stress and lipid peroxidation

A chemical probe to directly modulate the incorporation of TRF1 into shelterin would be a valuable tool to interrogate telomere maintenance mechanisms and a potential starting point for the development of novel anti-cancer therapeutics targeting the shelterin complex