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In two randomised controlled trials (RCT) in patients with coexisting ID anaemia and sub-clinical hypothyroidism, treatment with iron and L-T4 together was considerably more effective in improving iron status than was treatment with iron alone ( Reference Ravanbod, Asadipooya and Kalantarhormozi 60 , Reference Cinemre, Bilir and Gokosmanoglu 61 )

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Preventing the chronic progression of insomnia requires early therapeutic intervention and regenerative modulation of neural and neurochemical circuits