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Substantial weight loss achieved through GLP-1 therapy might therefore improve RA symptoms by reducing this inflammatory burden
In rats, liraglutide decreases food intake when directly injected into the ARC, LHA, or PVN while direct administration into the VMH decreases body weight without affecting food intake, but increases the expression of Ucp1 in the brown and inguinal white adipose tissue [666]
However, many report symptom improvement after several weeks
Exendin-4, a stable synthetic form of GLP-1, is commonly used clinically for diabetes treatment because GLP-1 has a short half-life (Drucker and Nauck, 2006
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