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4,5 Recent studies indicate that this reduction is not due to cell death, but rather to -cell identity loss 6,7,8,9,10 a process in which cells lose their mature phenotype, dedifferentiate into progenitor-like cells, or transdifferentiate into other pancreatic endocrine cells under chronic diabetic stress or owing to genetic defects

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Other subgroup analyses including follow-up time (S16 Fig in S1 File), GLP-1Ra type (S17 Fig in S1 File), BMI (S18 Fig in S1 File), and age (S19 Fig in S1 File), all had P values greater than 0.1, and between groups all had I 2 values below 50%

Novo Nordisk and Eli Lilly have both built extensive patent portfolios around their injection pensFlexTouch and KwikPen, respectively