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Combination strategies that integrate antioxidant, anti-inflammatory, epigenetic and neurotrophic approaches, together with approved medications for AUD and structured psychosocial interventions, may offer the greatest potential for preserving brain structure and function [11,21,48]

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Table 6: Treatment of folate deficiency (adapted from Means 2021) 27 TOP Ongoing Care Ongoing Management Vitamin B 12 Duration of therapy Once a diagnosis of B 12 deficiency due to poor absorption of B 12 has been made, therapy should be maintained lifelong

Consequently, taking a highly bioavailable glutathione supplement is essential so that the nutrient reaches the cells that need it most