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Future studies need to move beyond the linear explanatory framework based on a single metabolite or a single enzyme and systematically clarify, from the perspectives of temporal resolution and tissue niche resolution, the cooperative relationships between different amino acid metabolic axes and the TCA cycle, OXPHOS, and other immunometabolic modules (139)

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The results of a placebo-controlled trial in 276 healthy postmenopausal women suggested that supplementing the diet with alkali, either through supplemental potassium citrate or an additional 300 g/day of fruit and vegetables, did not reduce bone turnover, increase bone mineral density (BMD), or blunt the age-associated bone loss over a two-year period (45)