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Notably, p53-dependent activation of GLS-2 expression correlates with ROS, while elevated ROS levels lead to p53 stabilization and activation [89]

Pretreatment with L-NNA (20 mg/kg i.p.) produced a small but significant increment in MDA and 4-HNE level, as compared with that recorded in PTX-treated animals and addition of L-arginine (50 mg/kg i.g.) to L-NNA (20 mg/kg i.p.) significantly restored the contents of lipid peroxidation products to the values detected in PTX-treated rats ( Fig.6 )

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