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14 Recommendations The results above have prompted the ADA and EASD to recommend GLP-1RAs as preferred second- or third-line injectable agents following metformin in people with: 1 established atherosclerotic cardiovascular disease a need to minimise weight gain or promote weight loss a need to minimise hypoglycaemia mild-to-moderate chronic kidney disease

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It reduces blood volume, forcing your heart to work harder to pump oxygen and nutrients to your muscles and brain