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For example, if you have a history of allergies or sensitive skin, you might be more prone to developing a rash

Inform patients of the signs and symptoms of acute kidney injury and instruct them to promptly report any of these signs or symptoms or persistent (or extended) nausea, vomiting, and diarrhea to their healthcare provider [see Warnings and Precautions (5.5)]

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This decline in production worsens with a high stress lifestyle, poor eating habits or poor quality food, excessive toxins like smoking, alcohol or environmental pollutants and poor sleep amongst other reasons