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This metabolic reprogramming leads to the continuous production and accumulation of large amounts of lactate, which in turn causes acidification of the TME, promoting cancer cell growth, migration, and angiogenesis ( In addition, glucose transport plays a crucial role in regulating tumor glycolysis

10.1111/j.1523-1755.2004.00969.x 148 TkachenkoA.AlfhiliM

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