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Prior studies have demonstrated that neural circuits such as the BLA-PFC, VTA-BLA, and hippocampus(Hip)-BLA are involved in the regulation of anxiety and depressive states [6,10,19]

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Fat biopsy A small amount (about 1 g) of abdominal subcutaneous adipose tissue was collected under local anesthesia using a needle biopsy technique and snap frozen in liquid nitrogen

As a broad melanocortin receptor agonist active at MC1R, MC3R, MC4R and MC5R, it engages a wider receptor profile than Melanotan I, making it one of the most mechanistically versatile melanocortin compounds available for pigmentation, appetite and sexual-function signalling research in 2026