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Theyre looking at a clinical endpoint
In a mouse model of SCA6, BDNF and TrkB were downregulated at the age-at-onset, and early activation of TrkB-AKT signalling improved symptoms 59 , supporting our previously unappreciated findings whereby early manipulation of TrkB signalling regulated pathways in which GSH metabolism is crucial to halt the degenerative process triggered in iSPNs lacking BDNF-TrkB signalling
"Psilocybin seems to loosen up stereotyped patterns of brain activity and give people the ability to revise entrenched patterns of thought," said Taylor Lyons, PhD, a research associate at Imperial College London and the first author of the paper
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