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Men are also more likely to develop conditions associated with reduced glutathione or higher oxidative stress, including, More visceral fat than women, which drives insulin resistance 49 Higher rates of sleep apnea, another contributor to oxidative stress 50 Cardiovascular disease, which occurs about 710 years earlier in men than in women on average 51 As estrogen declines through perimenopause and menopause for womenand remains lower in men overalldifferences in glutathione activity likely reflect hormonal influence as much as sex-based biology, Tennant says

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Glutathione is a tripeptide antioxidant produced by our bodies that plays a really important role in protecting our proteins and DNA from damage caused by free radicals and oxidative stress

A schematic summary of these mechanisms, risk factors, and protective recommendations is illustrated in Fig