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Oxymetazoline vs Brimonidine for Management of Persistent Facial Erythema Oxymetazoline is an alpha-1a adrenoceptor agonist that causes topical vasoconstriction to lessen erythema associated with rosacea.6 Brimonidine is also a vasoconstrictor, though, it works through selective alpha-2 adrenergic agonism to exert its vasoconstricting effect.7 Brimonidine has a rapid onset within 30 minutes and begins to wear off at 10 to 12 hours at which point some patients report the return of erythema