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The study also noted that Candida can cause direct destruction of heart valves and contribute to embolism in a substantial proportion of cases

However, as gallbladder disease is not an issue with sodium-glucose co-transporter-2 (SGLT-2) inhibitors (with similar weight loss) (89), and gallbladder events also occurred in GLP-1RA-treated patients well after weight reduction (90), other mechanisms are possibly in play