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Abstract The mucopolysaccharidoses (MPS) are a heterogeneous group of in-born metabolic conditions caused by genetic defects that result in the absence or severe deficiency of one of the lysosomal hydrolases responsible for the degradation of glycosaminoglycans (GAGs)

And going way, way back, like a hundred years ago, even in the 1800s, more than a hundred years ago, the writers at the time observed that people who had diabetes were more prone to mental illness and vice versa