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Ubiquitination and degradation of p61 by the E3 ubiquitin ligase TRIM21 leads to failure of p61-mediated Nrf2 activation, which reduces the antioxidant capacity of tumor cells and makes them more prone to ferroptosis

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Dosing appears to play a role some trials have shown antioxidant effects with 800mg/day, while others suggest stronger responses at 1,2002,400mg/day, particularly for lowering oxidative stress biomarkers in patients with multiple sclerosis.3 28 Keep in mind, though: while higher doses (typically 1,2002,400mg per day) may offer stronger antioxidant effects, they also come with a greater chance of side effects like upset stomach or dizziness

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