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GLP-1RA interventions may reduce the incidence of recurrent AP, particularly SEMA and tirzepatide

Consistently, the co-transfection assay of COP1-binding defective DET1 mutants including R488A/H485G, R488A/H485G/R306G/S312G and R488A/H485G/E380A/T382A with COP1 and Ube2e2 demonstrated that the reduction of COP1-DET1 interaction resulted in the decreased amount of Ube2e2 co-purification, suggesting that DET1-mediated proximity is not sufficient for COP1 and Ube2e2 to directly interact (Fig

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PMID: 19136019 PMID: 12834882 Reference Reading Foundational Design Paper 1989 Cyclic-lactam -MSH analogs including Melanotan II origin and melanotropic potency Al-Obeidi, Castrucci, Hadley, and Hruby reported the design and synthesis of the 23-membered lactam-bridged cyclic heptapeptide (this compound) and documented 100-fold enhanced melanotropic potency vs -MSH in the lizard skin bioassay