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The drug had struggled in late-stage testing: September 2025 data from a phase 3 trial disappointed Wall Street, and a second phase 3 readout in January cleared its primary endpoint but stumbled on secondary measures

In practice, the schedule is a guide rather than a rigid timetable

Does High Plasma B12 Concentrations or High B12 Intake Cause Cancer From the studies discussed above and in Supplemental Data File S1 and Tables S3S11, we evaluated a possible causal link between elevated plasma vitamin B12 and cancer, according to the Bradford-Hill criteria of causality (Table 2)

IL-6, a key proinflammatory cytokine, is upregulated in multiple OA-related joint compartments, including synovial tissue, cartilage, and synovial fluid, where it promotes matrix degradation and inflammation (39)