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LiPo cells IR increases slowly with time and usage, an inevitable and irreversible process

Uses Cancer treatment (high doses): Leukemia Lymphomas Breast, head & neck cancers Choriocarcinoma Autoimmune & inflammatory conditions (low doses): Rheumatoid arthritis (RA) Psoriasis & psoriatic arthritis Systemic lupus erythematosus (SLE) Crohns disease & ulcerative colitis Juvenile idiopathic arthritis Mechanism of Action Inhibits dihydrofolate reductase (DHFR) prevents folic acid conversion to tetrahydrofolate blocks DNA, RNA, and protein synthesis

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[DOI] [PubMed] [Google Scholar] [172].Skyler JS, Bakris GL, Bonifacio E, Darsow T, Eckel RH, Groop L, Groop PH, Handelsman Y, Insel RA, Mathieu C, McElvaine AT, Palmer JP, Pugliese A, Schatz DA, Sosenko JM, Wilding JP, Ratner RE, Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis, Diabetes, 66 (2017) 241255