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The leap from "complementary mechanisms in animals" to "effective and safe synergy in humans" has not been made by the evidence

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This pattern promising small trials followed by null large trials is one of the most common failure modes in pharmaceutical development

Focused experiments conducted in rat striatum synaptosome preparations have reported that melatonin inhibits the excitatory response in a partially Ca 2+ -dependent manner in which the direct effect on membrane hyperpolarization promoted intracellular Ca 2+ influx reduction 94