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Nausea hits 28% of users, vomiting 17%, diarrhea 24%, and constipation 21%

However, the timing of the 22-week assessment differs from Study 023 in which, based on the study design, key outcomes were assessed at 52 weeks of active therapy, and exploratory, placebo-controlled outcomes were assessed at 14 weeks from baseline

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Riboflavin administration has been shown to be effective against TT genotype-associated hyperhomocysteinemia (89) and confirmed to be an independent determinant of homocysteine levels in those individuals (90)