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Heightened lactate production is evident in muscles, serum, and cerebrospinal fluid of ME/CFS patients following exercise, indicating significant dysregulation in exercise-induced metabolic activity, including an accelerated switching to aerobic glycolysis, increasing lactate production and suppressing ATP levels ( Neuroinflammation is an important mechanism related to pain syndromes such as fibromyalgia and CFS

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Al-Karaghouli, M., & Fang, F