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A simplified reaction is shown below: 2 GSH + H 2 O 2 GSSG + 2 H 2 O Glutathione reductase (GR) changes GSSG back to GSH by using NADPH: GSSG + NADPH + H + 2 GSH + NADP + GPx and GR form the main GSH/GSSG recycling cycle
S., Kathariou, S
Similarly, zinc is a structural and functional component of multiple antioxidant enzymes, including SOD, which catalyzes the dismutation of O 2 into HO and O 2 , reducing the toxicity of free radicals
Glutathione, Aging, and Oxidative Stress Oxidative damage is a major focus in aging research, and glutathione is central to many of these investigations: Glutathione levels appear to decline with age in many tissues, including the brain, with a corresponding increase in oxidative markers after a delay
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