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Here's what the research shows: 8,9 Weight Loss Comparison: Metformin: Average weight loss of 5-6 pounds (2-6% of body weight) Semaglutide: Average weight loss of 8-15 pounds (8-15% of body weight) Tirzepatide: Average weight loss of 15-20% of body weight Key Advantages of Metformin: Oral medication (no injections required) Significantly lower cost 60+ years of proven safety data 1 Can be used in combination with GLP-1 medications 10 Long-term effectiveness demonstrated over 15 years 2 Widely available and covered by most insurance plans Many healthcare providers now prescribe metformin alongside newer medications, leveraging the complementary benefits of both approaches for optimal weight management and metabolic health

[19] [20] Clinical trials show Zepbound reduces systolic blood pressure by 6-8 mmHg and diastolic pressure by 2-4 mmHg on average over 72 weeks

( Wegovy , a semaglutide that is approved for weight loss, has already established such a registry.) In the scientific literature, theres at least one such retrospective case of a woman who didnt know she was pregnant taking semaglutide up until about the fourth week of her pregnancy

Your healthcare provider will ask about your symptoms and medical history