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This phospholipid bilayer acts as a protective shield

Clinical Relevance of Glutathione Peroxidase 4 GPX4 represents an intriguing specific target for new pharmacological treatments, precision therapies, and other therapeutics

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Future optimization strategies include the development of brain-targeted prodrugs (e.g., ester modifications, peptide conjugation), the design of nanodelivery systems (PLGA, liposomes, exosome encapsulation) to enhance brain accumulation, and the identification of next-generation RTA molecules (such as SRS1192 and SRS16-86) with improved bloodbrain barrier permeability and metabolic stability