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The link between mitochondria and PD was first reported in 1983 when 1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP), a neurotoxin that interferes with respiratory chain complexes, was found to cause parkinsonian-like symptoms in drug users [120]

86 Some evidence suggests individuals with MTHFR polymorphisms may need higher doses of folic acid to experience therapeutic benefits and may respond better to supplementation with 5-methyltetrahydrofolate (5-MTHF), the active form of this B vitamin

These findings are most likely related to GH-induced calcitriol synthesis ( vide supra ), with consecutively increased intestinal calcium absorption, as calcitriol levels tend to be elevated in these patients [108]