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Unlike MT-1 whose linear backbone and tridecapeptide length confer preferential MC1R activity, MT-IIs cyclic heptapeptide structure produces a more compact, conformationally rigid pharmacophore with enhanced affinity at the centrally expressed MC3R and MC4R subtypes alongside maintained MC1R activity and generating the distinctive multi-system pharmacological profile that encompasses skin pigmentation through MC1R, pro-sexual and pro-erectile effects through hypothalamic and limbic MC3R/MC4R activation, and anorexia and energy balance modulation through hypothalamic MC3R/MC4R

Am J C/in Nuir 1989:50:301-6

[DOI] [PubMed] [Google Scholar] 139.Mannervik B, Board PG, Hayes JD, Listowsky I, Pearson WR

We can see several possibilities, which are not mutually exclusive