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GLP1-RAs, due to their anti-inflammatory and weight-reducing properties, could serve as an early intervention in HS, targeting both metabolic dysfunction and inflammation, which are critical in HS pathogenesis

Since vitamin B12 is primarily found in animal products, those who avoid meat, dairy, or eggs may develop low B12 levels over time

There are potential limitations of their use in clinical studies

In patients with HFpEF and obesity, both semaglutide and tirzepatide improve NYHA class, physical function, and quality of life independent of glycemic control, suggesting a glucose and weight-independent mechanism linked to anti-inflammatory and hemodynamic effects [5, 11]