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Given the constrained sample sizes, particularly for the HIV-positive ( n = 7) and HIV/TB co-infected ( n = 9) groups, influenced by the WHOs test-and-treat policy, the exploratory nature of this study is geared more towards providing a foundational understanding and shaping future inquiries rather than establishing definitive new biomarkers

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Reduction of Hyperinsulinaemia and IGF-1 Signalling Elevated circulating insulin and insulin-like growth factor-1 (IGF-1) represent well-established promoters of tumour cell proliferation

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