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In the LEAD-6 trial, overall adverse events were lower with the liraglutide group, compared with exenatide twice daily (74.9% versus 78.9%, respectively) but the severity of these effects where higher with liraglutide (serious AEs 5.1%, severe AEs 7.2%) than exenatide twice daily (serious AEs 2.6%, severe AEs 4.7%) [Buse et al

After careful reading of the remaining articles, 29 studies were removed, because the exposure/event of interest was not reported

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Mice homozygous for a dominant negative Pax6 mutation (SEYNeu) have repressed Gcg expression in enteroendocrine cells in the small and large bowel and absence of immunoreactive GLP-1 and GLP-2 [109]