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While the risk of developing new stones is probably much lower, because the gallbladder is more strongly stimulated to contract and expel bile on a high-fat KD, existing stones are more likely to migrate into the cystic duct and common bile duct

Search Strategy A comprehensive search of PubMed/MEDLINE and the Cochrane Central Register of Controlled Trials (CENTRAL) was performed from database inception through the final search date

Additionally, reviewing the official Prescribing information for bacteriostatic diluents provides essential context regarding chemical stability, pH ranges, and the physical properties of these solutions

Regarding drug dosing and safety, high doses may lead to toxicity, while low doses may not achieve sufficient therapeutic effects