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Are there negative long-term effects

Preclinical studies confirmed that it stimulates lipolysis by upregulating beta-3 adrenergic receptor (beta-3 AR) expression in adipose tissue, restoring the lipolytic responsiveness that is suppressed in obese animals

HIF1 is a transcription factor that can bind to hypoxia response elements in promoters, which leads to the transcription of genes involved in cell survival, proliferation and autophagy (258260)