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In addition, smoking and alcohol depletes vitamin C from the body

To counteract this process, the body has to produce new molecules of glutathione

Therefore, it is reasonable using supplementation of liposomal glutathione, instead of the N-acetylcysteine or bonded cysteine utilized as precursors for GSH cell synthesis, since patients with deficient levels of glutamate-cysteine ligase and GSH synthetase will not be able to use N-acetylcysteine or bonded cysteine as substrates to synthesize their own GSH

Managing hypoxia by HIFs Hypoxia represents another key factor inducing cellular perception and oxidative stress [477]