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In hippocampal neural cells grown in glucose-depleted media, LC also prevented the reduction in mitochondrial membrane potential and the formation of ROS

Exp Mol Med (2023) 55(4):70615

As a result, data mining alone does not provide sufficient evidence to establish causality and primarily emphasizes the need for practitioner vigilance

Current human safety data obtained under approved therapeutic regimens are characterized predominantly by mild-to-moderate gastrointestinal adverse events rather than generalized cytotoxic toxicity, underscoring the need to distinguish preclinical pro-apoptotic observations from clinically established safety profiles