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Taken together, this review provides a rationale for the use of trimetazidine as a promising repurposing candidate to treat bipolar depression

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Increased hepatic glucose production contributes to the development of MASLD by driving hyperglycemia and consequent hyperinsulinemia, but hyperglycemia per se (independent of insulin) can also promote liver lipid accumulation by promoting the nuclear translocation of carbohydrate-responsive element binding protein (69)