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They are expressed in human skin 33, 34 and in the coronary circulation

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Neurol Neurochir Pol 44(1):6579 Claire VC, Larrive B (2017) Tumor angiogenesis and vascular normalization: alternative therapeutic targets

7 Clinical outcomes of pharmacotherapy To date, numerous clinical studies including double- or single-blinded randomized clinical trials and split-face studies have been conducted to assess the therapeutic effect of various topical conventional and novel formulations in melasma management as summarized in Table 3